Daniel Batlle Selected Research

Angiotensin-Converting Enzyme 2

1/2022	A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection.
3/2021	A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection.
2/2021	A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids.
1/2020	The ACE2-deficient mouse: A model for a cytokine storm-driven inflammation.
1/2020	Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
1/2020	Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers.
1/2018	Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation.
1/2017	Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy.
9/2012	Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2.
8/2012	Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice.

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Daniel Batlle Research Topics

Disease

14	Hypertension (High Blood Pressure) 11/2020 - 07/2002
12	Diabetic Nephropathies (Diabetic Nephropathy) 12/2019 - 12/2002
8	Chronic Renal Insufficiency 01/2022 - 12/2005
7	Acidosis 01/2022 - 09/2006
7	COVID-19 01/2022 - 01/2020
6	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 09/2019 - 11/2006
5	Inflammation (Inflammations) 11/2020 - 11/2002
5	Albuminuria 01/2017 - 11/2006
4	Kidney Diseases (Kidney Disease) 11/2020 - 02/2008
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2019 - 09/2002
4	Secondary Hyperparathyroidism 02/2006 - 04/2003
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 03/2010
3	Fibrosis (Cirrhosis) 11/2020 - 08/2008
3	Hypokalemia 01/2018 - 11/2006
3	Heart Failure 12/2017 - 03/2010
3	Respiratory Alkalosis 09/2017 - 11/2006
3	Anemia 10/2011 - 11/2002
3	Hyperphosphatemia 02/2009 - 04/2003
2	Infections 01/2022 - 01/2020
2	Hyperkalemia 01/2022 - 11/2015
2	Fanconi Syndrome (Syndrome, Fanconi) 09/2019 - 12/2012
2	Diabetes Mellitus 01/2019 - 12/2005
2	Hyperglycemia 12/2018 - 11/2002
2	Acute Kidney Injury (Acute Renal Failure) 12/2017 - 10/2008
2	Type 2 Diabetes Mellitus (MODY) 04/2014 - 03/2012
2	Cysts 02/2009 - 08/2008
2	Hypercalcemia (Milk Alkali Syndrome) 02/2006 - 04/2003
2	Proteinuria 12/2005 - 11/2002
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Lung Injury 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Masked Hypertension 10/2020
1	Cytokine Release Syndrome 01/2020
1	Coronavirus Infections 01/2020
1	Severe Acute Respiratory Syndrome 01/2020
1	Growth Disorders 01/2018
1	Muscle Weakness 01/2018
1	Cardiomegaly (Heart Hypertrophy) 01/2018
1	Nephrolithiasis 01/2018
1	Nephrocalcinosis 01/2018
1	Hypercalciuria 01/2018

Drug/Important Bio-Agent (IBA)

15	Angiotensin-Converting Enzyme 2IBA 01/2022 - 11/2006
10	Angiotensin IIIBA 11/2020 - 04/2005
7	PotassiumIBA 01/2022 - 11/2006
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2009
6	Bicarbonates (Hydrogen Carbonate)IBA 01/2022 - 01/2007
4	AngiotensinsIBA 01/2022 - 05/2008
4	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2020 - 04/2005
4	AngiotensinogenIBA 10/2019 - 01/2016
4	AcidsIBA 01/2018 - 11/2006
4	SodiumIBA 01/2018 - 07/2002
4	Biomarkers (Surrogate Marker)IBA 12/2017 - 08/2013
4	paricalcitol (Zemplar)FDA Link 02/2006 - 04/2003
3	EnzymesIBA 11/2020 - 05/2008
3	angiotensin I (1-7)IBA 01/2020 - 01/2018
3	Peptides (Polypeptides)IBA 01/2020 - 05/2008
3	ReninIBA 01/2019 - 08/2010
3	Streptozocin (Streptozotocin)FDA Link 01/2019 - 01/2017
3	AldosteroneIBA 01/2018 - 04/2005
3	AlkaliesIBA 01/2018 - 12/2010
3	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 08/2017 - 11/2006
3	CalciumIBA 02/2009 - 04/2003
3	Parathyroid Hormone (Parathormone)IBA 01/2006 - 04/2003
2	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2022
2	Glucose (Dextrose)FDA LinkGeneric 09/2019 - 12/2012
2	Phosphates (Orthophosphate)IBA 09/2019 - 12/2012
2	Amino Acids FDA Link 09/2019 - 12/2012
2	Pharmaceutical PreparationsIBA 09/2019 - 12/2012
2	Uric Acid (Urate)IBA 09/2019 - 12/2012
2	dirhodium tetraacetate (DRTA)IBA 01/2018 - 10/2012
2	Protons (Proton)IBA 01/2018 - 04/2005
2	Ammonium CompoundsIBA 09/2017 - 01/2007
2	ElectrolytesIBA 03/2017 - 02/2007
2	Proton-Translocating ATPases (ATPase, H+)IBA 10/2012 - 04/2005
2	AlbuminsIBA 08/2012 - 09/2002
2	Antihypertensive Agents (Antihypertensives)IBA 10/2011 - 09/2003
2	Erythropoietin FDA Link 01/2007 - 11/2002
2	Capsules (Microcapsules)IBA 02/2006 - 01/2006
2	Phosphorus (Red Phosphorus)IBA 02/2006 - 04/2003
2	Calcitriol (Calcijex)FDA LinkGeneric 01/2006 - 04/2003
2	Vitamin D FDA LinkGeneric 12/2005 - 04/2003
2	Hormones (Hormone)IBA 12/2005 - 04/2005
2	IronIBA 09/2003 - 01/2003
1	Nucleic AcidsIBA 01/2022
1	sodium zirconium cyclosilicateIBA 01/2022
1	VaccinesIBA 01/2022
1	Type 1 Angiotensin ReceptorIBA 11/2020
1	Recombinant ProteinsIBA 11/2020
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2020
1	InterleukinsIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 12/2019
1	Sodium-Phosphate Cotransporter Proteins (Sodium-Phosphate Cotransporter)IBA 09/2019
1	MineralocorticoidsIBA 01/2018
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2018
1	CarboxypeptidasesIBA 01/2018
1	Amiloride (Midamor)FDA LinkGeneric 01/2018
1	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2018

Therapy/Procedure

11	Therapeutics 01/2022 - 04/2003
2	Injections 01/2017 - 11/2002
1	Precision Medicine 10/2020